hCD44v6/MC-38
CBPG0190
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| I. Background | |
| CD44v6 基因是 CD44 基因的一种拼接变异体，其编码的 CD44v6 蛋白是一种跨膜糖蛋 白，属于细胞黏附分子家族成员。该基因位于人类第 11 号染色体短臂，在转录过程中，通 过选择性剪接形成包含变异型外显子 v6 的剪接体。CD44v6 主要在具有转移能力的癌细胞 中表达，能够改变细胞间及细胞与基质间的粘连，增强肿瘤细胞的转移潜力。研究发现， CD44v6 在食管癌、乳腺癌、非小细胞肺癌、白血病和胃癌等多种恶性肿瘤组织中高表达， 与肿瘤的发生、开展及转移密切相关。CD44v6 顺利获得与透明质酸等配体结合，介导细胞黏 附和信号传导，促进肿瘤细胞的侵袭和转移。因此，CD44v6 被认为是肿瘤转移促进基因， 是判断肿瘤生物学行为及预后的重要标志，也为肿瘤治疗给予了潜在的靶点。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hCD44v6 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hCD44v6/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hCD44v6/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
